10mg/1ml Chlorpheniramine Injection / Chlorphenamine Maleate
Product : Chlorpheniramine Maleate Injection
Specification : 10mg/1ml
Standard : BP, USP
Packing : 10 x 10amps/box
Chlorpheniramine is a histamine H1 antagonist used in allergic
reactions, hay fever, rhinitis, urticaria, and asthma. It has also
been used in veterinary applications. One of the most widely used
of the classical antihistaminics, it generally causes less
drowsiness and sedation than promethazine.
Indications and Usage :
Chlorphenamine injection is indicated for acute urticaria, control
of allergic reactions to insect bites and stings, angioneurotic
oedema, drug and serum reactions, desensitisation reactions,
hayfever, vasomotor rhinitis, severe pruritus of non-specific
The usual dose of chlorphenamine injection for adults is 10mg to
20mg, but not more than 40mg should be given within a 24-hour
period. The injection may be given by the subcutaneous,
intramuscular or intravenous route.
When a rapid effect is desired, as in anaphylactic reactions, the
intravenous route is recommended in addition to emergency therapy
with adrenaline (epinephrine), corticosteroids, oxygen and
supportive therapy as required. In this case chlorphenamine
injection should be injected slowly over a period of one minute,
using the smallest adequate syringe. Any drowsiness, giddiness or
hypotension which may follow is usually transitory.
In the event of a blood transfusion reaction, a dose of 10mg to
20mg of chlorphenamine injection should be given by the
subcutaneous route. This can be repeated to a total of 40mg within
a 24-hour period, or oral forms of chlorphenamine may be given
until the symptoms subside.
Chlorphenamine injection may be helpful in the prevention of
delayed reactions to penicillin and other drugs when given
separately by intramuscular injection immediately prior to
administration of the other drug. The usual dose is 10mg.
Chlorphenamine injection cannot, however, be relied on to prevent
anaphylactic reactions in patients known to be allergic to a
The dose for children should be calculated, based on either the
child's age or their body weight, using the following table:
|1 month to 1 year||0.25mg/kg|
|1 to 5 years||2.5mg to 5mg||OR||0.20mg/kg|
|6 to 12 years||5mg to 10mg||OR||0.20mg/kg|
|12 to 18 years||10mg to 20mg||OR||0.20mg/kg|
Extra care should be taken when preparing the injection for
children under 1 year due to the small volumes that are required.
Dilution of chlorphenamine injection with sodium chloride
intravenous infusion (0.9% w/v) should facilitate preparation. For
example, diluting 0.2ml chlorphenamine injection to 2ml with sodium
chloride 0.9% injection produces a solution containing
In allergic reactions an allergen interacts with and cross-links
surface IgE antibodies on mast cells and basophils. Once the mast
cell-antibody-antigen complex is formed, a complex series of events
occurs that eventually leads to cell-degranulation and the release
of histamine (and other chemical mediators) from the mast cell or
basophil. Once released, histamine can react with local or
widespread tissues through histamine receptors. Histamine, acting
on H1-receptors, produces pruritis, vasodilatation, hypotension,
flushing, headache, tachycardia, and bronchoconstriction. Histamine
also increases vascular permeability and potentiates pain.
Chlorpheniramine, is a histamine H1 antagonist (or more correctly,
an inverse histamine agonist) of the alkylamine class. It competes
with histamine for the normal H1-receptor sites on effector cells
of the gastrointestinal tract, blood vessels and respiratory tract.
It provides effective, temporary relief of sneezing, watery and
itchy eyes, and runny nose due to hay fever and other upper
Mechanism of action :
Chlorpheniramine binds to the histamine H1 receptor. This blocks
the action of endogenous histamine, which subsequently leads to
temporary relief of the negative symptoms brought on by histamine.