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Vitamin K1 Phylloquinone Small Volume Injection 10mg / 1ml

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Newlystar (Ningbo) Medtech Co.,Ltd.
City: Ningbo
Province/State: Zhejiang
Country/Region: China
Tel: 86-574-8701-9333
Contact Person:
Mr Luke Liu

Vitamin K1 Phylloquinone Small Volume Injection 10mg / 1ml

Brand Name : Newlystar
Place of Origin : China
MOQ : 300, 000 amps
Payment Terms : L/C, T/T
Delivery Time : 45days
Packaging Details : 10 x 10amps/box
Model Number : 10mg / 1ml
Certification : GMP
Price : Negotiation
Supply Ability : one million amps per day
Product : Vitamin K1 Injection Phylloquinone Injection
Specification : 10mg / 1ml
Standard : BP, USP
Packing : 10 x 10amps/box
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Vitamin K1 Phylloquinone Small Volume Injection 10mg/ml


Product : Vitamin K1 Injection Phylloquinone Injection

Specification : 10mg / 1ml

Standard : BP, USP

Packing : 10 x 10amps/box


Description :

Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.


Indications and Dosages :

to prevent hypoprothrombinemia during prolonged use of total parenteral nutrition

i.m. injection

Adults. 5 to 10 mg/wk.

Children. 2 to 5 mg/wk.

to prevent hypoprothrombinemia in infants with diets deficient in vitamin k (less than 100 mcg/l)

i.m. injection

Infants. 1 mg/mo.

to treat anticoagulant-induced hypoprothrombinemia tablets,

i.m. or subcutaneous injection

Adults. 2.5 to 25 mg, repeated 12 to 48 hr after P.O. dose or 6 to 8 hr after SubQ or I.M. dose, as prescribed. Maximum: 50 mg/dose.

Children. 2.5 to 10 mg SubQ or I.M., repeated in 6 to 8 hr, as prescribed.

Infants. 1 to 2 mg SubQ or I.M., repeated in 4 to 8 hr, as prescribed.

to treat hypoprothrombinemia from other causes

tablets, i.m. or subcutaneous injection

Adults. 2 to 25 mg. Usual: 25 mg. Maximum: 50 mg/dose.

Children. 5 to 10 mg SubQ or I.M.

Infants. 2 mg SubQ or I.M.

to prevent hemorrhagic disease in neonates

i.m. or subcutaneous injection

Neonates. 0.5 to 1 mg within 1 hr after birth, repeated in 6 to 8 hr, as prescribed.

to treat hemorrhagic disease in neonates

i.m. or subcutaneous injection

Neonates. 1 mg (or higher dose if mother took an oral anticoagulant or anticonvulsant during pregnancy).


Pharmacodynamics :

Phylloquinone is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phylloquinone aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).


Mechanism of action :

Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.


Product Tags:

Small Volume Injection

      
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