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Irinotecan Hydrochloride Injection Therapy For Metastatic Colorectal Cancer

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Newlystar (Ningbo) Medtech Co.,Ltd.
City: Ningbo
Province/State: Zhejiang
Country/Region: China
Tel: 86-574-8701-9333
Contact Person:
Mr Luke Liu

Irinotecan Hydrochloride Injection Therapy For Metastatic Colorectal Cancer

Brand Name : Newlystar
Place of Origin : China
MOQ : 2000 vials
Payment Terms : L/C, T/T
Delivery Time : 45days
Packaging Details : 10 vials/box
Model Number : 40mg/2ml,100mg/5ml
Certification : GMP
Price : Negotiation
Supply Ability : 50, 000 vials per
Product : Irinotecan Hydrochloride Injection
Specification : 40mg/2ml,100mg/5ml
Standard : BP, USP
Packing : 10 vials/box
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Irinotecan Hydrochloride Injection For Metastatic Colorectal Cancer


Product : Irinotecan Hydrochloride Injection

Specification : 40mg/2ml,100mg/5ml

Standard : BP, USP

Packing : 10 vials/box


Description :

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015.


Indication and Dosage

For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.

To treat colorectal cancer: 125 mg/m2 I.V. over 90 min every wk for 4 wk, followed by 2 wk of no drug, then repeat 6-wk cycle; or 350 mg/m2 I.V. over 90 min every 3 wk


Pharmacodynamics

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a semisynthetic derivative of camptothecin. Camptothecins interact specifically with topoisomerase I, an enzyme in the cell nucleus that regulates DNA topology and facilitates nuclear processes such as DNA replication, recombination, and repair. During these processes, topoisomerase I relieves torsional strain in DNA by inducing reversible single-strand breaks, allowing single DNA strands to pass through the break. The 3'-DNA terminus of the broken DNA strands bind covalently with the topoisomerase enzyme to form a catalytic intermediate called a cleavable complex. After the DNA is sufficiently relaxed and the strand passage reaction is complete, DNA topoisomerase reattaches the broken DNA strands to form the chemically unaltered topoisomers that allow transcription to proceed. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either Irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks. The precise contribution of SN-38 to the activity of irinotecan in humans is not known. Irinotecan is cell cycle phase-specific (S-phase).


Mechanism of action

Irinotecan inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex. The formation of this ternary complex interferes with the moving replication fork, which induces replication arrest and lethal double-stranded breaks in DNA. As a result, DNA damage is not efficiently repaired and apoptosis (programmed cell death) occurs.


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